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- · 醫(yī)用臭氧配合羥考酮緩釋劑治療中重度癌痛的臨床觀察 (八)
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免疫三氧自血療法對尋常型銀屑病病人外周血VEGF 和 HIF-1α 表達的影響(二)
- 發(fā)布時間:2020-09-02
- 瀏覽次數(shù):441次
免疫三氧自血療法對尋常型銀屑病病人外周血VEGF 和 HIF-1α 表達的影響(一)
王杰, 李睿亞 , 段妍, 莎娜
( 內(nèi)蒙古自治區(qū)醫(yī)院 皮膚性病科,內(nèi)蒙古 呼和浩特 010020)
WANG Jie, LI Rui-ya, DUAN Yan, et al.
( Inner Mongolia Hospital,Hohhot 010020 China)
Abstract: Objective: This project aims to observe the change of medical ozone on psoriasis vulgaris and its impact on VEGF and HIF-1α in serum and try to discorver the possible mechanism of medical ozone in treating psoriasis vulgaris. Methods: 70 patients with psoriasis vulgaris were assigned to join this study and were equally divided into the treatment group( medical ozone) and the control group( Compound indigo naturalis pills) .The period of treatment was 8 weeks.Besides,a normal control group including 20 healthy volunteers was set up. This project respectively observed the PASI in the treatment group and the control group,adopted the enzyme linked immunosorbent assay to test the before and after treatment of these two groups on the contents change of peripheral blood,and did the related analysis according to corresponding score.Results: The PASI scores were significantly decreased after treatment in both groups,but the decrement in treatment group was more significant than that in control group.The total clinical effective rates in treatment group was 88.57%,while control group were 57.14%; therefore,therapeutic effect in treatment group is superior to that in control group.The level of VEGF and HIF- 1α in serum in two groups before treatment was obviously higher than those in the healthy control.After treatment,the levels of VEGF and HIF-1α in serum were significantly decreased in both groups,and the changes in treatment group were more significant than those in control group. There was a positive correlation between the level of VEGF or HIF-1α and PASI scores of psoriatic pa-tients,but there was not a correlation between VEGF and HIF-1α.Conclusion: Medical ozone is effec- tive and safe in the treatment of psoriatic vulgaris,and when VEGF and HIF-1α in peripheral blood of psoriatic patients. are abnoemal,medical ozone can correct abnormal VEGF and HIF- 1α,so as to a- chieve a therapeutic effect.
Key words: psoriasis; medical ozone; vascular endothelial growth factor; hypoxia-inducible factor-1α
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